Organo-Metalloid Compounds
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- (217)
- (154)
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- (1)
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- (258)
- (84)
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- (32)
- (54)
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- (1)
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- (19)
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- (9)
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- (9)
- (1)
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- (1)
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- (1)
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- (1)
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- (1)
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- (9)
- (1)
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- (1)
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- (10)
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- (1)
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- (1)
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Filtered Search Results
Medchemexpress LLC Bis-PEG5-acid 5g | 439114-13-3 | 338.35 g·mol⁻1 | C14H26O9 | 5 G
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Bis-PEG5-acid is a polyethylene glycol (PEG)-based bifunctional linker with two terminal carboxylic acid groups, used as a hydrophilic spacer in PROTAC synthesis, bioconjugation, and medicinal chemistry to improve solubility and provide flexibility between binding motifs.
- Provides a flexible PEG5 spacer for conjugation and linker design.
- Two terminal carboxylic acid groups for straightforward coupling chemistry.
- High purity (99.9%) suitable for research applications.
- Available in laboratory pack sizes for small-scale synthesis.
- Enhances aqueous solubility of hydrophobic ligands and intermediates.
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Medchemexpress LLC THP-PEG5-OH | 100MG
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THP-PEG5-OH | 100MG
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Medchemexpress LLC DNP-PEG3-azide | 951671-87-7 | 99.2% | C14H20N6O7 | 25 MG
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DNP-PEG3-azide is a PEG-based PROTAC linker crucial for the synthesis of PROTACs. It acts as a click chemistry reagent, featuring an azide group that enables both copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne groups and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. It is a light yellow to yellow viscous liquid with a high purity of 99.18%.
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Medchemexpress LLC Bromoacetamido-PEG3-NH-Boc | 1421933-39-2 | ≥98.0% | C15H29BrN2O6 | 1 G
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Bromoacetamido-PEG3-NH-Boc is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs feature two distinct ligands connected by a linker, one binding to an E3 ubiquitin ligase and the other to the target protein, enabling the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- PEG-based linker
- Utilized in the synthesis of PROTACs
- Connects ligands for E3 ubiquitin ligase and target proteins
- Enables selective degradation of target proteins
- Molecular weight: 413.30
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Medchemexpress LLC Boc-NH-PEG5-CH2CH2COOH | 1347750-78-0 | MFCD24539478 | 99.9% | 409.47 g/mol | C18H35NO9 | 100 MG
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Boc-NH-PEG5-CH2CH2COOH is a Boc-protected PEG5 linker containing a protected amine and a terminal ethyl carboxylic acid, intended for use in the synthesis of PROTAC molecules and other linker-dependent conjugates. It is a mid-sized PEG derivative offering predictable reactivity for coupling chemistries and convenient handling in common organic solvents.
- Boc-protected amine facilitates orthogonal deprotection
- PEG5 spacer provides flexible linker length
- Terminal ethyl carboxylic acid enables amide coupling
- High solubility in DMSO for stock solutions
- Stable under recommended cold storage conditions
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Medchemexpress LLC N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid | 2183440-74-4 | 98.1% | C29H55N5O13 | 50 MG
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N-(Azido-PEG3)-N-(PEG2-NH-Boc)-PEG3-acid | 2183440-74-4 | 98.1% | C29H55N5O13 | 50 MG
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Medchemexpress LLC N-(Amino-PEG3)-N-bis(PEG4-Boc) | 2353409-57-9 | 98.0% | C38H76N2O15 | 100 MG
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N-(Amino-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two different ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets the protein of interest. These molecules exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Applicable in cancer-programmed cell death research
- Connects two different ligands for PROTAC formation
- Targets E3 ubiquitin ligase and protein of interest
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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Medchemexpress LLC 2-(2-(2-bromoethoxy)ethoxy)ethyl methanesulfonate | 2702323-73-5 | 95.0% | 291.16 | C7H15BrO5S | 5 MG
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Br-PEG3-MS is a brominated, PEG-based PROTAC linker (methanesulfonate) designed for use in chemical synthesis of PROTACs and other bifunctional molecules. It provides a short PEG3 spacer with a reactive leaving group for conjugation chemistry, enabling efficient formation of linkages between ligands under standard organic conditions. For research use only.
- PEG3 spacer with a terminal bromide and methanesulfonate leaving group.
- Suitable for linker synthesis and nucleophilic substitution reactions.
- High purity (95.0% by NMR) for reliable synthetic performance.
- Low molecular weight facilitates handling in small-scale reactions.
- Available in multiple small pack sizes to support medicinal chemistry workflows.
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Medchemexpress LLC N-(Azido-PEG3)-N-bis(PEG4-acid) | 2112731-54-9 | 98.0% | C30H58N4O15 | 50 MG
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N-(Azido-PEG3)-N-bis(PEG4-acid) is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This compound acts as a click chemistry reagent, featuring an Azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions when combined with Alkyne groups. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an Azide group
- Undergoes copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with Alkyne groups
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups
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![eMolecules 100900-07-0 | 5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt | Combi-Blocks, Inc. | MFCD00051474 | 288.300 | C12H13N2NaO3S | 95.000 | [Na+].NCCNc1cccc2c(cccc12)S([O-])(=O)=O | 1g | 603153060](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502184524.JPG-250.jpg)
eMolecules 100900-07-0 | 5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt | Combi-Blocks, Inc. | MFCD00051474 | 288.300 | C12H13N2NaO3S | 95.000 | [Na+].NCCNc1cccc2c(cccc12)S([O-])(=O)=O | 1g | 603153060
5-(2-Aminoethylamino)-1-naphthalenesulfonic acid sodium salt | Combi-Blocks, Inc. | 100900-07-0 | MFCD00051474 | 288.300 | C12H13N2NaO3S | 95.000 | [Na+].NCCNc1cccc2c(cccc12)S([O-])(=O)=O | 1g | 603153060
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CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502183485.JPG-250.jpg)
eMolecules 2243566-42-7 | m-PEG5-triethoxysilane | Broadpharm483.674 | C21H45NO9Si | 96.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972
m-PEG5-triethoxysilane | Broadpharm | 2243566-42-7483.674 | C21H45NO9Si | 96.000 | CCO[Si](CCCNC(=O)CCOCCOCCOCCOCCOC)(OCC)OCC | 1g | 411413972
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Medchemexpress LLC Chloro-PEG5-chloride 1g
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Chloro-PEG5-chloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.9% | 322.75 | 1 ML
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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PS-1145 | 431898-65-6 | 99.9% | 322.75 | 1 ML
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Chemscene ChemScene | 4-(Trimethylsilyl)benzeneboronic acid | 10G | CS-W001042 | 0.98 | 17865-11-1| MFCD00093348 | 194.12
ChemScene | 4-(Trimethylsilyl)benzeneboronic acid | 10G | CS-W001042 | 0.98 | 17865-11-1| MFCD00093348 | 194.12
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Medchemexpress LLC PS-1145 | 431898-65-6 | 99.67% | 322.75 | 25 MG
Small and Specialty Supplier Partner
Small and/or specialty supplier based on Federal laws and SBA requirements.
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
- Blocks TNFα-induced NF-κB activation in a dose- and time-dependent manner in MM cells through inhibition of IκBα phosphorylation.
- Dexamethasone enhances the blockade of NF-κB activation by the product.
- Blocks the protective effect of IL-6 against Dexamethasone-induced apoptosis.
- Inhibits TNFα-induced intracellular adhesion molecule (ICAM)-1 expression.
- Inhibits both IL-6 secretion from bone marrow stromal cells (BMSCs) triggered by MM cell adhesion and proliferation of MM cells adherent to BMSCs.
- Administration results in a significant decrease in serum levels of three cytokines.
- Blocks hypothalamic inflammation induced by IL-4.
- Decreases IL-1β mRNA content.
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